UPSC CMS PSM - Genetics & Preventive Medicine

Autosomal dominant inheritance is characterized by:

Consider the following statements:

1. An affected heterozygous parent typically has a 50% chance of transmitting the variant in each pregnancy, with both sexes affected.
2. In the context of the question, “Only males affected” is the most appropriate conclusion.

Which of the statements given above is/are correct?

An X-linked recessive disorder is typically transmitted from:

Consider the following statements:

1. Sons receive their single X chromosome from the mother; affected fathers do not transmit an X-linked trait to sons.
2. In the context of the question, “An affected father to all sons” is the most appropriate conclusion.
3. In the context of the question, “A carrier mother to affected sons” is the most appropriate conclusion.

Which of the statements given above is/are correct?

A couple attending preventive and genetic counselling requests an evidence-based interpretation.

Mitochondrial disorders are inherited through:

Select the single best answer.

Hardy-Weinberg equilibrium requires:

Consider the following statements:

1. In the context of the question, “Strong selection” is the most appropriate conclusion.
2. In the context of the question, “Complete assortative mating” is the most appropriate conclusion.

Which of the statements given above is/are correct?

If the frequency of a recessive disease is q², the approximate carrier frequency is:

Consider the following statements:

1. Heterozygous carriers have frequency 2pq in Hardy-Weinberg equilibrium; for a rare allele, p is close to 1.
2. In the context of the question, “p²” is the most appropriate conclusion.

Which of the statements given above is/are correct?