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UPSC CMS General Medicine - Infectious Diseases & Global Health

Attempt UPSC CMS General Medicine - Infectious Diseases & Global Health under real exam conditions. Features timed computer-based test interface, textbook explanations, and detailed subject rank analytics.

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Real CBT Simulator Grid & Percentile
Duration
10 Mins
Countdown timer with review palette.
Marking Scheme
+4.00 / -1.00
Exact negative marking as per official exam rules.
Textbook Citations
Harrison & Bailey
Standard medical textbook solution references.
Target Exam
UPSC CMS
Official paper pattern & syllabus coverage.

📝 Sample Question Preview from UPSC CMS General Medicine - Infectious Diseases & Global Health

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Question 1
A 32-year-old male presents with sudden onset high-grade fever, chills, severe headache, and retro-orbital pain. He reports a recent travel history to an endemic area. On examination, he has petechial rash, hepatomegaly, and a positive tourniquet test. Laboratory investigations reveal thrombocytopenia and hemoconcentration. Which of the following statements regarding the management and complications of this condition is/are CORRECT? 1. IV fluids should be restricted to prevent fluid overload and pulmonary edema. 2. Aspirin and NSAIDs are contraindicated due to the risk of bleeding. 3. The patient should be monitored for signs of plasma leakage and shock, particularly during the defervescence phase. 4. Intravenous corticosteroids are recommended for severe cases to reduce inflammation.
A. 1 and 2 only
B. 2 and 3 only
C. 1, 3 and 4 only
D. 2, 3 and 4 only
Textbook Explanation Highlight:
The clinical presentation is highly suggestive of dengue fever with warning signs. Statement 1 is incorrect: Fluid resuscitation is crucial in dengue, especially with warning signs like hemoconcentration and plasma leakage, although aggressive fluid...
Question 2
Which of the following statements regarding the diagnosis and management of Tuberculosis (TB) is INCORRECT?
A. The Xpert MTB/RIF assay can simultaneously detect Mycobacterium tuberculosis and rifampicin resistance.
B. For drug-sensitive pulmonary TB, the standard treatment regimen involves 6 months of daily rifampicin, isoniazid, pyrazinamide, and ethambutol.
C. Patients with latent TB infection (LTBI) should always be treated to prevent progression to active disease.
D. Tuberculous meningitis typically requires a longer duration of treatment, often including corticosteroids, compared to pulmonary TB.
Textbook Explanation Highlight:
Statement 3 is incorrect. While treatment of latent TB infection (LTBI) is recommended for high-risk groups (e.g., immunocompromised, recent contacts), it is not a universal recommendation for all individuals with LTBI, as the risk of progression to...
Question 3
A 45-year-old construction worker presents with chronic cough, progressive dyspnea, and recurrent fever for the past 6 months. He has a history of exposure to pigeon droppings and a large amount of dust at his workplace. Chest X-ray shows bilateral reticulonodular infiltrates. Bronchoalveolar lavage (BAL) reveals encapsulated yeast forms. Which of the following antifungals is CONTRADICTED as initial treatment given his clinical presentation and likely diagnosis?
A. Amphotericin B
B. Fluconazole
C. Voriconazole
D. Itraconazole
Textbook Explanation Highlight:
The clinical picture of chronic cough, dyspnea, reticulonodular infiltrates, history of pigeon droppings exposure, and encapsulated yeast forms in BAL is highly suggestive of Cryptococcosis, likely Cryptococcus neoformans. The initial treatment for s...
Question 4
Which of the following is most strongly associated with the 'Rose spots' clinical sign?
A. Leishmaniasis
B. Typhoid fever
C. Malaria
D. Rickettsial disease
Textbook Explanation Highlight:
Rose spots are a classic, though not always present, clinical finding in typhoid fever (enteric fever), caused by Salmonella Typhi or Paratyphi. They are transient, blanching, erythematous maculopapular lesions typically found on the trunk and chest...
Question 5
A 28-year-old female presents with acute onset fever, severe muscle pain, and headache after returning from a trekking trip in a tropical rainforest. She noticed a black eschar on her axilla which she initially dismissed. Laboratory findings show thrombocytopenia, elevated liver enzymes, and leukopenia. The Weil-Felix test reveals agglutination with OX-K antigen. What is the most likely diagnosis?
A. Typhus fever
B. Leptospirosis
C. Dengue fever
D. Scrub typhus
Textbook Explanation Highlight:
The clinical presentation (acute fever, myalgia, headache, eschar, travel history to tropical rainforest, thrombocytopenia, elevated liver enzymes) combined with the positive Weil-Felix test for OX-K antigen is highly diagnostic of Scrub Typhus. Scru...
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